Acute alcohol administration dampens central extended amygdala reactivity
نویسندگان
چکیده
منابع مشابه
Intrinsic functional connectivity of the central extended amygdala.
The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)-plays a critical role in triggering fear and anxiety and is implicated in the development of a range of debilitating neuropsychiatric disorders. Although it is widely believed that these disorders reflect the coordinated activity of distributed neural circuits, th...
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It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST), the two major subdivisions of the central extended amygdala. Early versions of this hypothesis remain highly influential and have been incorporated into the National Institute of Mental Health Rese...
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Genetic predisposition and exposure to alcohol and stress increase the risk for alcoholism, possibly by forming a threefold interaction. This is suggested by various aspects of alcohol-induced stress response dampening in offspring of alcoholics. We tested whether such an interaction is also revealed by prolactin secretion, which is predominantly controlled by hypothalamic dopamine. Plasma prol...
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The Neuropeptide S receptor, a Gs/Gq-coupled GPCR expressed in brain regions involved in mediating drug reward, has recently emerged as a candidate therapeutic target in addictive disorders. Here, we describe the in vitro and in vivo pharmacology of a novel, selective and brain penetrant NPSR antagonist with nanomolar affinity for the NPSR, NCGC00185684. In vitro, NCGC00185684 shows biased anta...
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Annika Thorsell,1,3* Jenica D. Tapocik,1* Ke Liu,2* Michelle Zook,1 Lauren Bell,1 Meghan Flanigan,1 Samarjit Patnaik,2 Juan Marugan,2 Ruslan Damadzic,1 Seameen J. Dehdashti,2 Melanie L. Schwandt,1 Noel Southall,2 Christopher P. Austin,2 Robert Eskay,1 Roberto Ciccocioppo,4 Wei Zheng,2* and Markus Heilig1 1Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-34987-3